Diffinity Genomics is a U.S. life science start-up company with technologies that enable the development of high margin, single use disposable products for medical, industrial and research applications in two very large and rapidly growing markets; DNA extraction and purification and molecular diagnostics.  DNA extraction and purification customers include the 390,000 life science workers engaged in DNA analysis worldwide, spread among 45,000 industrial and academic research labs. The company is currently manufacturing and selling its first product, the Diffinity RapidTip for PCR Purification, to a very receptive market.

Diffinity Technology is based upon differential adsorption of different forms of nucleic acids on specially tailored surfaces.  Our initial product, the Diffinity RapidTip for PCR purification,  provides a revolutionary new way of performing purification of PCR (polymerase chain reaction) product in a single step.Diffinity Genomics' mission is to successfully commercialize its nucleic acid adsorption technologies and all related research, medical and industrial applications; to stimulate research in the field; and to enable company shareholders, founders, strategic partners, management and employees to realize their personal, business, scientific and humanitarian objectives.

Diffinity Genomics’ products are based on a platform technology for chemically sequestering nucleic acids through selective adsorption.  This differential affinity (“diffinity”) can be used in many ways, including purifying mixtures of DNA or RNA as well as testing for the presence or absence of a specific genetic target.

Diffinity technology breaks traditional nucleic acid purification paradigms by directly binding impurities (such as nucleotides, primers, and primer-dimers) on our proprietary surfaces while allowing double stranded DNA targets (such as PCR amplicons) to remain in solution.  This methodology allows simple, rapid, and inexpensive purification inside a pipette tip or column without any additional buffers or reagents.

•    One minute PCR purification in a single step!

•    No bind-wash-elute, enzymes, or use of magnetic beads!

The Diffinity RapidTip functional pipette tip contains everything you need for PCR purification. The tip is filled with our proprietary adsorption technology that has a differential affinity for PCR reaction components. The impurities (e.g., single-stranded primers and nucleotides used in the PCR process) are removed from the solution as it enters the pipette tip. Dispensing the solution yields purified, high quality DNA ready to use in your next application. You don’t need to use any capital equipment, reagents or buffers, or enzymes — all you need is a pipettor!

The functional pipette tip will fit on most conventional single or multiple, manual or automated laboratory pipettors.  Samples containing DNA and impurities are aspirated into the tip where the impurities are adsorbed onto proprietary surfaces within the tip by mixing for approximately one minute.  Expelling the solution yields purified DNA, the desired product.

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